| 12:00 PM | Northwestern @ 8 Wisconsin | ABC | Bob Wischusen, Dan Orlovsky |
| 12:00 PM | Texas Tech @ 6 Oklahoma | FOX | Gus Johnson, Joel Klatt |
| 12:00 PM | Arkansas vs 23 Texas A&M
(in Arlington TX) | ESPN | Mark Jones, Dusty Dvoracek |
| 12:00 PM | Middle Tennessee @ 14 Iowa | ESPN2 | Kevin Brown, Andre Ware |
| 12:00 PM | Kansas @ TCU | FS1 | Brian Custer, Robert Smith |
| 12:00 PM | Buffalo @ Miami (OH) | ESPNU | Mike Couzens, Kirk Morrison |
| 12:00 PM | Northern Illinois @ Vanderbilt | SECN | Dave Neal, DJ Shockley |
| 12:00 PM | Rutgers @ 20 Michigan | BTN | Kevin Kugler, Matt Millen |
| 12:00 PM | Holy Cross @ Syracuse | ACCN | Wes Durham, Roddy Jones, Eric Wood |
| 12:00 PM | Central Michigan @ Western Michigan | CBSSN | Jason Horowitz, Danny Kanell |
| 12:00 PM | BYU @ Toledo | ESPN+ | Michael Reghi, Dustin Fox |
| 12:30 PM | Delaware @ Pittsburgh | ACC RSNs | Tom Werme, James Bates |
| 3:30 PM | 1 Clemson @ North Carolina | ABC | Dave Pasch, Greg McElroy, Tom Luginbill |
| 3:30 PM | Ole Miss @ 2 Alabama | CBS | Brad Nessler, Gary Danielson |
| 3:30 PM | 21 USC @ 17 Washington | FOX | Joe Davis, Brock Huard |
| 3:30 PM | 18 Virginia @ 10 Notre Dame | NBC | Mike Tirico, Doug Flutie |
| 3:30 PM | Iowa State @ Baylor | ESPN | Steve Levy, Brian Griese, Todd McShay |
| 3:30 PM | Minnesota @ Purdue | ESPN2 | Marc Kestecher, Rod Gilmore, Quint Kessenich |
| 3:30 PM | Indiana @ 25 Michigan State | BTN | Brandon Gaudin, James Laurinaitis |
| 3:30 PM | Wake Forest @ Boston College | ACCN | Chris Cotter, Mark Herzlich |
| 3:30 PM | Georgia Tech @ Temple | CBSSN | Rich Waltz, Aaron Murray |
| 3:30 PM | FAU @ Charlotte | NFLN | Dan Hellie, Max Starks |
| 3:30 PM | Akron @ Massachusetts | FloSports | |
| 3:30 PM | Coastal Carolina @ Appalachian State | ESPN+ | |
| 4:00 PM | Southern Methodist @ South Florida | ESPNU | Anish Shroff, Ahmad Brooks |
| 4:00 PM | Towson @ 9 Florida | SECN | Taylor Zarzour, Matt Stinchcomb |
| 5:00 PM | Cincinnati @ Marshall | CBS Sports Facebook | Ben Holden, Ross Tucker |
| 6:00 PM | Arkansas State @ Troy | ESPN+ | |
| 6:00 PM | East Carolina @ Old Dominion | ESPN+ | |
| 6:00 PM | ULL @ Georgia Southern | ESPN+ | |
| 6:00 PM | New Mexico @ Liberty | ESPN+ | |
| 7:00 PM | Mississippi State @ 7 Auburn | ESPN | Sean McDonough, Todd Blackledge |
| 7:00 PM | Connecticut @ 22 UCF | ESPN2 | Roy Philpott, Kelly Stouffer |
| 7:00 PM | Stanford @ Oregon State | P12N | Roxy Bernstein, Anthony Herron |
| 7:00 PM | UAB @ Western Kentucky | ESPN+ | |
| 7:00 PM | 24 Kansas State @ Oklahoma State | ESPN+ | Mark Neely, Ray Bentley |
| 7:00 PM | South Alabama @ ULM | ESPN+ | |
| 7:00 PM | UTEP @ Southern Mississippi | ESPN+ | |
| 7:00 PM | Louisiana Tech @ Rice | ESPN3 | |
| 7:00 PM | Nicholls State @ Texas State | ESPN3 | |
| 7:30 PM | 5 Ohio State @ Nebraska | ABC | Chris Fowler, Kirk Herbstreit |
| 7:30 PM | Kentucky @ South Carolina | SECN | Tom Hart, Jordan Rodgers, Cole Cubelic |
| 7:30 PM | N.C. State @ Florida State | ACCN | Dave O’Brien, Tim Hasselbeck |
| 7:30 PM | Colorado State @ Utah State | CBSSN | Carter Blackburn, Aaron Taylor |
| 8:00 PM | Washington State @ 19 Utah | FS1 | Justin Kutcher, Petros Papadakis, Shane Vereen |
| 8:00 PM | UNLV @ Wyoming | ESPNU | Mike Corey, Rene Ingoglia |
| 8:00 PM | Houston @ North Texas | CBS Sports Facebook | Dave Ryan, Corey Chavous |
| 8:00 PM | Fresno State @ New Mexico State | FSN Ariz+, FloSports | |
| 10:30 PM | UCLA @ Arizona | ESPN | Beth Mowins, Anthony Becht, Rocky Boiman |
| 10:30 PM | Hawaii @ Nevada | ESPN2 | Clay Matvick, Ryan Leaf |
